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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Protection against dimethylhydrazine-induced adenomatous tumors of the mouse colon by the dietary addition of an extract of soybeans containing the Bowman-Birk protease inhibitor.

Authors: Weed, H G; McGandy, R B; Kennedy, A R

Published In Carcinogenesis, (1985 Aug)

Abstract: Dimethylhydrazine (DMH) induces adenocarcinomas of the colon and rectum in rodents; this animal cancer model system is thought to closely resemble human colorectal cancer. An extract of soybeans containing the Bowman-Birk protease inhibitor added to the diet of DMH-treated mice resulted in a significant suppression of adenomatous tumors of the colonic mucosa. Non-treated mice maintained on the same diet for most of their natural life-span (1.5 years) showed no observable health problems.

PubMed ID: 4040444 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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