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Title: Alveolar epithelial beta2-adrenergic receptors.

Authors: Mutlu, Gokhan M; Factor, Phillip

Published In Am J Respir Cell Mol Biol, (2008 Feb)

Abstract: beta(2)-adrenergic receptors are present throughout the lung, including the alveolar airspace, where they play an important role for regulation of the active Na(+) transport needed for clearance of excess fluid out of alveolar airspace. beta(2)-adrenergic receptor signaling is required for up-regulation of alveolar epithelial active ion transport in the setting of excess alveolar edema. The positive, protective effects of beta(2)-adrenergic receptor signaling on alveolar active Na(+) transport in normal and injured lungs provide substantial support for the use of beta-adrenergic agonists to accelerate alveolar fluid clearance in patients with cardiogenic and noncardiogenic pulmonary edema. In this review, we summarize the role of beta(2)-adrenergic receptors in the alveolar epithelium with emphasis on their role in the regulation of alveolar active Na(+) transport in normal and injured lungs.

PubMed ID: 17709598 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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