Title: Hepatitis B virus infection contributes to oxidative stress in a population exposed to aflatoxin B1 and high-risk for hepatocellular carcinoma.

Authors: Liu, Zhi-Ming; Li, Le-Qun; Peng, Min-Hao; Liu, Tang-Wei; Qin, Zhong; Guo, Ya; Xiao, Kai-Yin; Ye, Xin-Ping; Mo, Xin-Shao; Qin, Xue; Li, Shan; Yan, Lu-Nan; Shen, Han-Ming; Wang, LianWen; Wang, Qiao; Wang, Kai-bo; Liang, Ren-xiang; Wei, Zong-liang; Ong, Choon Nam; Santella, Regina M; Peng, Tao

Published In Cancer Lett, (2008 May 18)

Abstract: Biomarkers of hepatitis B virus (HBV) infection, aflatoxin B1 (AFB1) exposure and oxidative stress were detected in 71 hepatocellular carcinoma (HCC) patients and 694 controls from southern China. Plasma level of AFB1-albumin-adducts (AAA) and protein carbonyl content (PCC) were significantly higher in the 71 HCC cases than in any age/gender matched HBV sero-status groups (p<0.001). HCC patients positive for the p53-249 G-T mutation had a marginally higher level of PCC than those negative for the mutation (p=0.077). HBV infection had a prominent influence on the association between AFB1 exposure and oxidative stress biomarkers in the controls. Our study indicates a significant contribution from HBV infection to oxidative stress in a population with AFB1 exposure which might substantially increase risk for HCC in this region.

PubMed ID: 18280645

MeSH Terms: Adult; Aflatoxin B1/toxicity*; Biomarkers/analysis; Carcinoma, Hepatocellular/virology*; Female; Hepatitis B/complications*; Humans; Liver Neoplasms/virology*; Male; Middle Aged; Oxidative Stress/physiology*; Risk