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National Institute of Environmental Health Sciences

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Publication Detail

Title: Minimize the detection of false positives by the software program DetectShift for 18O-labeled cross-linked peptide analysis.

Authors: Gao, Quixia; Xue, Song; Shaffer, Scott A; Doneanu, Catalin E; Goodlett, David R; Nelson, Sidney D

Published In Eur J Mass Spectrom (Chichester), (2008)

Abstract: In order to speed up the process of cross-linked peptide identification and characterization, we have previously reported the development of Pro-CrossLink, a suite of software tools consisting of three programs, DetectShift, IdentifyXLink and AssignXLink for mass spectrometric data analysis. Since its public disclosure, Pro-CrossLink has been downloaded by 101 research groups. Pro-CrossLink users have provided us with valuable feedback on the use of the DetectShift program. Here we assess some reasons for the generation of false positives by DetectShift. In addition, we provide users with suggestions on optimal parameter setting and efficient use of the software program.

PubMed ID: 19023145 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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