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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: UVB irradiation regulates Cox-2 mRNA stability through AMPK and HuR in human keratinocytes.

Authors: Zhang, Jack; Bowden, G Tim

Published In Mol Carcinog, (2008 Dec)

Abstract: Considerable evidence has demonstrated that UVB irradiation is a strong carcinogen for nonmelanoma skin cancer. Up-regulation of cyclooxygenase-2 (Cox-2) has been shown to be a crucial event in human keratinocytes in their responses to UVB irradiation. To further understand the molecular mechanisms governing Cox-2 regulation, we found that UVB irradiation significantly increased Cox-2 mRNA stability by inducing cytoplasmic localization and protein abundance of human antigen R (HuR). We also found that AMP-activated kinase (AMPK) mediates these events and that UVB reduces AMPK activity by down-regulating LKB1 kinase. Finally, we propose a novel model in which UVB regulates Cox-2 mRNA stability through the LKB1/AMPK pathway.

PubMed ID: 18449856 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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