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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Protein tyrosine nitration--an update.

Authors: Ischiropoulos, Harry

Published In Arch Biochem Biophys, (2009 Apr 15)

Abstract: Tyrosine nitration is a covalent post-translational protein modification derived from the reaction of proteins with nitrating agents. Tyrosine nitration has been used as a marker of oxidant burden in human diseases. However, it remains unclear whether protein nitration is responsible for alterations in protein function that imparts an increased risk for disease development or unfavorable outcomes. Emerging data implicate tyrosine nitration as a mediator of immune responses suggesting a novel biological function for this protein modification.

PubMed ID: 19007743 Exiting the NIEHS site

MeSH Terms: Humans; Immunoglobulins/biosynthesis; Nitrates/metabolism*; Nitric Oxide/metabolism; Nitrosation; Phenols/metabolism; Proteins/metabolism*; Superoxide Dismutase/metabolism; Tyrosine/metabolism*

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