Title: DNA polymerases at the eukaryotic fork-20 years later.
Authors: Pavlov, Youri I; Shcherbakova, Polina V
Published In Mutat Res, (2010 Mar 01)
Abstract: Function of the eukaryotic genome depends on efficient and accurate replication of anti-parallel DNA strands. Eukaryotic DNA polymerases have different properties adapted to perform a wide spectrum of DNA transactions. Here we focus on major players in the bulk replication, DNA polymerases of the B-family. We review the organization of the replication fork in eukaryotes in a historical perspective, analyze contemporary models and propose a new integrative model of the fork.
PubMed ID: 19682465
MeSH Terms: DNA Replication*; DNA-Directed DNA Polymerase/chemistry; DNA-Directed DNA Polymerase/metabolism*; Eukaryotic Cells; Models, Genetic*