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National Institute of Environmental Health Sciences

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Publication Detail

Title: Amide isosteres of oroidin: assessment of antibiofilm activity and C. elegans toxicity.

Authors: Richards, Justin J; Reyes, Samuel; Stowe, Sean D; Tucker, Ashley T; Ballard, T Eric; Mathies, Laura D; Cavanagh, John; Melander, Christian

Published In J Med Chem, (2009 Aug 13)

Abstract: The synthesis and antibiofilm activities of sulfonamide, urea, and thiourea oroidin analogues are described. The most active derivative was able to selectively inhibit P. aeruginosa biofilm development and is also shown to be nontoxic upward of 1 mM to the development of C. elegans in comparison to other similar isosteric analogues and the natural product oroidin.

PubMed ID: 19719234 Exiting the NIEHS site

MeSH Terms: Amides/chemical synthesis*; Amides/pharmacology; Amides/toxicity; Animals; Anti-Bacterial Agents/chemical synthesis*; Anti-Bacterial Agents/pharmacology; Biofilms/drug effects*; Caenorhabditis elegans/drug effects*; Pseudomonas aeruginosa/drug effects*; Pseudomonas aeruginosa/physiology; Pyrroles/chemical synthesis*; Pyrroles/pharmacology; Pyrroles/toxicity; Structure-Activity Relationship; Sulfonamides/chemical synthesis; Sulfonamides/pharmacology; Thiourea/chemical synthesis; Thiourea/pharmacology; Urea/chemical synthesis; Urea/pharmacology

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