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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Non-Hodgkin lymphoma (NHL) subtypes defined by common translocations: utility of fluorescence in situ hybridization (FISH) in a case-control study.

Authors: Chang, Cindy M; Schroeder, Jane C; Huang, Wen-Yi; Dunphy, Cherie H; Baric, Ralph S; Olshan, Andrew F; Dorsey, Kathleen C; Dent, Georgette A; Cerhan, James R; Lynch, Charles F; Rothman, Nathaniel; Cantor, Kenneth P; Blair, Aaron

Published In Leuk Res, (2010 Feb)

Abstract: We used fluorescence in situ hybridization (FISH) assays to identify t(14;18) translocations in archival paraffin-embedded tumor sections from non-Hodgkin lymphoma (NHL) cases enrolled in a population-based study. t(14;18) was identified in 54% of 152 cases, including 39% of diffuse large cell lymphomas (26 of 66 cases) and 84% of follicular lymphomas (36 of 43 cases). Eighty-seven percent of t(14;18)-positive cases and 57% of t(14;18)-negative cases expressed bcl-2. FISH assays detected twice as many t(14;18)-positive follicular lymphomas as PCR assays. Overall, study findings support the use of FISH assays to detect t(14;18) in archival tumor samples for epidemiologic studies of NHL subtypes.

PubMed ID: 19505720 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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