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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Acute urinary bladder toxicity of a polyurethane foam catalyst mixture: a possible new target organ for propionitrile derivative.

Authors: Jaeger, R J; Plugge, H; Szabo, S

Published In J Environ Pathol Toxicol, (1980 Sep)

Abstract: The toxicity of the mixture NIAX-ESN which contains 95% dimethylaminopropionitrile was evaluated in male rats. Large doses (2.0 ml/kg ip) rapidly produced CNS excitation followed by depression and death. The mixture (given orally as two doses of 0.31 or 0.62 ml/kg respectively) induced acute urinary bladder lesions in 3 days. The changes consisted of massive transmural edema, acute ulcers and inflammation and, occassionally hemorrhagic necrosis of the bladder wall.

PubMed ID: 7462919 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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