Title: Effects of methyl mercury on protein synthesis in vitro.
Authors: Syversen, T L
Published In Acta Pharmacol Toxicol (Copenh), (1981 Nov)
Abstract: Methyl mercury has been shown to interact with protein synthesis in vivo and in vitro. In the present paper a brain postmitochondrial supernatant was used for studies in vitro. Inorganic mercury (Hg2+) was shown to be more potent inhibitor of protein synthesis than methyl mercury, puromycin or cycloheximide. The inhibitory effect of methyl mercury was potentiated by puromycin. It is thus possible that methyl mercury causes disintegration of polysomes in brain cells.
PubMed ID: 7345883
MeSH Terms: No MeSH terms associated with this publication