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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Abnormalities of human chromosome 13 and in vitro radiosensitivity; a study of 19 fibroblast strains.

Authors: Nove, J; Nichols, W W; Weichselbaum, R R; Little, J B

Published In Mutat Res, (1981 Nov)

Abstract: The in vitro X-ray sensitivity of 19 fibroblast strains derived from patients bearing a deletion, trisomy, inversion, or translocation of all or part of chromosome 13 were determined with a clonogenic survival assay. The results were compared with data from similar experiments involving strains from normal controls and from individuals trisomic for 3 other autosomes. The results suggest the involvement of this chromosome with hypersensitivity to the cytotoxic effects of X-irradiation. Experiments involving the partial monosomies and trisomies seem to implicate a locus on 13q14.

PubMed ID: 7329430 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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