Title: Synthesis of [75Se]trimethylselenonium iodide from [75Se]selenocystine.
Authors: Foster, S J; Ganther, H E
Published In Anal Biochem, (1984 Feb)
Abstract: The synthesis of [75Se]trimethylselenonium iodide from [75Se]selenocystine is described. The starting compound is reduced to [75Se]selenocysteine with borohydride and reacted with methyl iodide to form [75Se]Se-methyl-selenocysteine, then treated with methyl iodide in formic acid solution to form Se-dimethyl-selenocysteine selenonium iodide. Over a period of days, the selenonium intermediate undergoes spontaneous elimination to form alanine and dimethyl selenide, which reacts with methyl iodide to give the trimethylselenonium product in over 90% yield.
PubMed ID: 6731798
MeSH Terms: No MeSH terms associated with this publication