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National Institute of Environmental Health Sciences

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Publication Detail

Title: Differential responses to methylmercury exposure and recovery in neuroblastoma and glioma cells and fibroblasts.

Authors: Sager, P R; Syversen, T L

Published In Exp Neurol, (1984 Aug)

Abstract: The effects of methylmercury (MeHg) on cytoplasmic microtubules in cultured neuroblastoma cells, glioma cells, and fibroblasts were compared. Neuroblastoma cells appeared to be more sensitive to disruption of microtubules by MeHg than the glioma cells or fibroblasts; cellular concentrations of mercury after MeHg were also higher in neuroblastoma cells. Recovery of microtubule structure was monitored in cells after removal of MeHg; addition of the chelating dimercaptosuccinic acid (DMSA) increased reassembly of microtubules. During MeHg treatment and early recovery, microtubule integrity was dependent on cellular mercury concentrations. However, after prolonged DMSA exposure, mercury appeared to reenter the cell, without causing dissociation of microtubules.

PubMed ID: 6086380 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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