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National Institute of Environmental Health Sciences

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Publication Detail

Title: G-protein-coupled receptors and melanoma.

Authors: Lee, Hwa Jin; Wall, Brian; Chen, Suzie

Published In Pigment Cell Melanoma Res, (2008 Aug)

Abstract: G-protein-coupled receptors (GPCR) are the largest family of receptors with over 500 members. Evaluation of GPCR gene expression in primary human tumors identified over-expression of GPCR in several tumor types. Analysis of cancer samples in different disease stages also suggests that some GPCR may be involved in early tumor progression and others may play a critical role in tumor invasion and metastasis. Currently, >50% of drug targets to various human diseases are based on GPCR. In this review, the relationships between several GPCR and melanoma development and/or progression will be discussed. Finally, the possibility of using one or more of these GPCR as therapeutic targets in melanoma will be summarized.

PubMed ID: 18582227 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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