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National Institute of Environmental Health Sciences

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Publication Detail

Title: Protective effects of the antioxidant 4b,5,9b,10-tetrahydroindeno[1,2-b]indole against TCDD toxicity in C57BL/6J mice.

Authors: Shertzer, Howard G

Published In Int J Toxicol, (2010 Jan-Feb)

Abstract: The protection against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; 5 microg/kg body weight) toxicity by the antioxidant 4b,5,9b,10-tetrahydroindeno[1,2-b]indole (THII) was examined in female C57BL/6J mice. TCDD produced increases in the levels of hepatic lipid-derived aldehydes, rates of mitochondrial production of hydrogen peroxide and superoxide, and the oxidation state of cytosolic GSH. In contrast, mitochondrial GSH increased in reduction state, correlating with an increase in mitochondrial membrane potential. Systemically, TCDD lowered body weight gain, percentage body fat, and hepatic ATP levels, parameters prevented by concomitant administration of 100 microM THII in drinking water. However, TCDD-induced increases in mitochondrial respiration and decreased mitochondrial membrane fluidity were not prevented by THII. These results suggest that TCDD-mediated oxidative stress was not responsible for changes in mitochondrial respiration or membrane fluidity. Furthermore, although TCDD produced a large increase in mitochondrial oxygen consumption, this was not associated with the poor gain in weight produced by TCDD.

PubMed ID: 19926830 Exiting the NIEHS site

MeSH Terms: Adipose Tissue/drug effects; Animals; Antioxidants/pharmacology*; Environmental Pollutants/toxicity*; Female; Glutathione/metabolism; Indoles/pharmacology*; Lipid Peroxidation/drug effects; Liver/drug effects*; Liver/metabolism; Malondialdehyde/metabolism; Membrane Fluidity/drug effects; Membrane Fluidity/physiology; Membrane Potential, Mitochondrial/drug effects; Membrane Potential, Mitochondrial/physiology; Mice; Mice, Inbred C57BL; Mitochondria, Liver/drug effects; Mitochondria, Liver/metabolism; Mitochondrial Membranes/drug effects; Mitochondrial Membranes/physiology; Oxidative Stress/drug effects*; Oxygen Consumption; Polychlorinated Dibenzodioxins/toxicity*; Reactive Oxygen Species/metabolism; Weight Gain

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Last Reviewed: October 07, 2024