Skip Navigation

Publication Detail

Title: A second genetic variant on chromosome 15q24-25.1 associates with lung cancer.

Authors: Liu, Pengyuan; Yang, Ping; Wu, Xifeng; Vikis, Haris G; Lu, Yan; Wang, Yian; Schwartz, Ann G; Pinney, Susan M; de Andrade, Mariza; Gazdar, Adi; Gaba, Colette; Mandal, Diptasri; Lee, Juwon; Kupert, Elena; Seminara, Daniela; Minna, John; Bailey-Wilson, Joan E; Spitz, Margaret; Amos, Christopher I; Anderson, Marshall W; You, Ming

Published In Cancer Res, (2010 Apr 15)

Abstract: A common variant on chromosomal region 15q24-25.1, marked by rs1051730, was found to be associated with lung cancer risk. Here, we attempted to confirm the second variant on 15q24-25.1 in several large sporadic lung cancer populations and determined what percentage of additional risk for lung cancer is due to the genetic effect of the second variant. SNPs rs1051730 and rs481134 were genotyped in 2,818 lung cancer cases and 2,766 controls from four populations. Joint analysis of these two variants (rs1051730 and rs481134) on 15q24-25.1 identified three major haplotypes (G_T, A_C, and G_C) and provided stronger evidence for association of 15q24-25.1 with lung cancer (P = 9.72 x 10(-9)). These two variants represent three levels of risk associated with lung cancer. The most common haplotype G_T is neutral; the haplotype A_C is associated with increased risk for lung cancer with 5.0% higher frequency in cases than in controls [P = 1.68 x 10(-7); odds ratio (OR), 1.24; 95% confidence interval (95% CI), 1.14-1.35]; whereas the haplotype G_C is associated with reduced risk for lung cancer with 4.4% lower frequency in cases than in controls (P = 7.39 x 10(-7); OR, 0.80; 95% CI, 0.73-0.87). We further showed that these two genetic variants on 15q24-25.1 independently influence lung cancer risk (rs1051730: P = 4.42 x 10(-11); OR, 1.60; 95% CI, 1.46-1.74; rs481134: P = 7.01 x 10(-4); OR, 0.81; 95% CI, 0.72-0.92). The second variant on 15q24-25.1, marked by rs481134, explains an additional 13.2% of population attributable risk for lung cancer.

PubMed ID: 20395203 Exiting the NIEHS site

MeSH Terms: African Americans; Alleles; Case-Control Studies; Chromosomes, Human, Pair 15*; European Continental Ancestry Group; Gene Expression Regulation, Neoplastic*; Genetic Variation*; Haplotypes; Humans; Lung Neoplasms/genetics*; Lung Neoplasms/metabolism; Models, Statistical; Odds Ratio; Polymorphism, Single Nucleotide*; Regression Analysis; Risk

Back
to Top
Last Reviewed: October 02, 2024