Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Dose-responsive gene expression changes in juvenile and adult mummichogs (Fundulus heteroclitus) after arsenic exposure.

Authors: Gonzalez, Horacio O; Hu, Jianjun; Gaworecki, Kristen M; Roling, Jonathan A; Baldwin, William S; Gardea-Torresdey, Jorge L; Bain, Lisa J

Published In Mar Environ Res, (2010 Aug)

Abstract: The present study investigated arsenic's effects on mummichogs (Fundulus heteroclitus), while also examining what role that gender or exposure age might play. Adult male and female mummichogs were exposed to 172 ppb, 575 ppb, or 1720 ppb arsenic as sodium arsenite for 10 days immediately prior to spawning. No differences were noted in the number or viability of eggs between the groups, but there was a significant increase in deformities in 1720 ppb arsenic exposure group. Total RNA from adult livers or 6-week old juveniles was used to probe custom macroarrays for changes in gene expression. In females, 3% of the genes were commonly differentially expressed in the 172 and 575 ppb exposure groups compared to controls. In the males, between 1.1 and 3% of the differentially expressed genes were in common between the exposure groups. Several genes, including apolipoprotein and serum amyloid precursor were commonly expressed in either a dose-responsive manner or were dose-specific, but consistent across genders. These patterns of regulation were confirmed by QPCR. These findings will provide us with a better understanding of the effects of dose, gender, and exposure age on the response to arsenic.

PubMed ID: 20451245 Exiting the NIEHS site

MeSH Terms: Animals; Arsenic/toxicity*; Body Burden; Dose-Response Relationship, Drug; Female; Fundulidae/genetics*; Fundulidae/growth & development; Gene Expression/drug effects*; Growth and Development/drug effects; Liver/metabolism; Male; Sex Factors; Water Pollutants, Chemical/toxicity*

Back
to Top