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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Exposure to naphthalene induces naphthyl-keratin adducts in human epidermis in vitro and in vivo.

Authors: Kang-Sickel, Juei-Chuan C; Stober, Vandy P; French, John E; Nylander-French, Leena A

Published In Biomarkers, (2010 Sep)

Abstract: We observed naphthyl-keratin adducts and dose-related metabolic enzyme induction at the mRNA level in reconstructed human epidermis in vitro after exposure to naphthalene. Immunofluorescence detection of 2-naphthyl-keratin-1 adducts confirmed the metabolism of naphthalene and adduction of keratin. We also observed naphthyl-keratin adducts in dermal tape-strip samples collected from naphthalene-exposed workers at levels ranging from 0.004 to 6.104 pmol adduct microg(-1) keratin. We have demonstrated the ability of the human skin to metabolize naphthalene and to form naphthyl-keratin adducts both in vitro and in vivo. The results indicate the potential use of keratin adducts as biomarkers of dermal exposure.

PubMed ID: 20500019 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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