Title: Serum bisphenol A pharmacokinetics and prostate neoplastic responses following oral and subcutaneous exposures in neonatal Sprague-Dawley rats.

Authors: Prins, Gail S; Ye, Shu-Hua; Birch, Lynn; Ho, Shuk-mei; Kannan, Kurunthachalam

Published In Reprod Toxicol, (2011 Jan)

Abstract: The present study examines BPA pharmacokinetics in neonatal rats following s.c. injection or oral delivery of 10 ýýg BPA/kg BW and compares susceptibility to estrogen-induced prostate intraepithelial neoplasia (PIN) following either exposure route. Serum BPA in PND3 rats was measured using HPLC-MS-MS. Free and total BPA at C(max) were 1.77 and 2.0 ng/ml, respectively following injection and 0.26 and 1.02 ng/ml, respectively following oral exposure. The AUC(0-2) for free and total BPA was 4.1-fold and 1.8-fold greater, respectively, in s.c. vs. oral delivery. While exposure route affected BPA metabolism, internal dosimetry following s.c. injection of 10 ýýg BPA/kg BW is similar to BPA levels observed in humans. Prostates from aged rats given s.c. or oral BPA neonatally and T+E implants as adults exhibited nearly identical, heightened susceptibility to PIN incidence and score as compared to neonatal oil-controls. These findings on prostate health are directly relevant to humans at current BPA exposure levels.

PubMed ID: 20887781

MeSH Terms: Administration, Oral; Animals; Animals, Newborn; Estrogens, Non-Steroidal/blood; Estrogens, Non-Steroidal/pharmacokinetics*; Estrogens, Non-Steroidal/toxicity*; Injections, Subcutaneous; Male; Phenols/blood; Phenols/pharmacokinetics*; Phenols/toxicity*; Prostatic Intraepithelial Neoplasia/chemically induced*; Prostatic Intraepithelial Neoplasia/metabolism; Prostatic Intraepithelial Neoplasia/pathology; Prostatic Neoplasms/chemically induced*; Prostatic Neoplasms/metabolism; Prostatic Neoplasms/pathology; Rats; Rats, Sprague-Dawley