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Title: Magnetic resonance spectroscopy and environmental toxicant exposure.

Authors: Weisskopf, Marc G

Published In Ann N Y Acad Sci, (2007 Feb)

Abstract: The study of neurological impacts of toxicants has emphasized neuropsychological tests as important outcome variables. Direct assessment of neural substrates of environmental impacts could offer many advantages. I discuss our use of magnetic resonance spectroscopy (MRS) in the neurological assessment of adult lead poisoning of monozygotic twins as an example. Cognitive testing showed frontal lobe dysfunction in both twins, and more dramatic hippocampal dysfunction in the twin with higher lead exposure (JG). MRS showed lower N-acetylaspartate/creatine ratios in JG. The findings illustrate the potential utility of MRS in assessing impacts of not only lead, but other toxicants as well.

PubMed ID: 17413022 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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