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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Exhaled NO among inner-city children in New York City.

Authors: Perzanowski, Matthew S; Divjan, Adnan; Mellins, Robert B; Canfield, Stephen M; Rosa, Maria Jose; Chew, Ginger L; Rundle, Andrew; Goldstein, Inge F; Jacobson, Judith S

Published In J Asthma, (2010 Nov)

Abstract: Fractional exhaled nitric oxide (FeNO) has been proposed as a biomarker of airway inflammation for cohort studies of asthma.To assess the association between FeNO and asthma symptoms among 7-year-old children living in an inner-city community. To test the association between environmental tobacco smoke (ETS) exposure (previous and current) and FeNO among these children.As part of a longitudinal study of asthma, children recruited in Head Start centers at age 4 had offline FeNO and lung function testing at age 7. Children with allergen-specific immunoglobulin E (IgE) (ýýý0.35 IU/mL) at age 7 were considered seroatopic. ETS exposure at ages 4 and 7 was assessed by questionnaire.Of 144 participating children, 89 had complete questionnaire data and achieved valid FeNO and lung function tests. Children with reported wheeze in the previous 12 months (n = 19) had higher FeNO than those without wheeze (n = 70) (geometric means 17.0 vs. 11.0 ppb, p = .005). FeNO remained significantly associated with wheeze (p = .031), after adjusting for seroatopy and forced expiratory volume in 1 second (FEVýýý) in multivariable regression. FeNO at age 7 was positively associated with domestic ETS exposure at age 4 (29%) (ýý = 0.36, p = .015) but inversely associated with ETS exposure at age 7 (16%) (ýý = -0.74, p < .001).Given its association with current wheeze, independent of seroatopy and lung function, FeNO provides a relevant outcome measure for studies in inner-city communities. While compelling, the positive association between ETS exposure at age 4 and a marker of airway inflammation at age 7 should be confirmed in a larger study.

PubMed ID: 20936992 Exiting the NIEHS site

MeSH Terms: Asthma/diagnosis*; Asthma/physiopathology; Biological Markers/analysis; Body Mass Index; Breath Tests; Child; Child, Preschool; Cohort Studies; Exhalation*; Female; Humans; Immunoglobulin E/blood; Inhalation Exposure/adverse effects*; Longitudinal Studies; Male; New York City; Nitric Oxide/analysis*; Poverty; Tobacco Smoke Pollution/analysis*; Urban Population

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