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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Chronic administration of ethanol leads to an increased incidence of hepatocellular adenoma by promoting H-ras-mutated cells.

Authors: Jeannot, Emmanuelle; Pogribny, Igor P; Beland, Frederick A; Rusyn, Ivan

Published In Cancer Lett, (2011 Feb 28)

Abstract: This study used tissue samples from male B6C3F1 mice treated with ethanol in drinking water (0%, 2.5%, or 5%) for 4 or 104 weeks. We tested whether chronic alcohol drinking promotes oxidative stress in the liver and characterized the mutation profile of spontaneous and ethanol-induced tumors. We show that ethanol does not cause detectable oxidative stress in the liver at any time point and acts by promoting H-ras mutated cells.

PubMed ID: 21168264 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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