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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Hemoglobin adducts in workers exposed to 1,6-hexamethylene diisocyanate.

Authors: Flack, Sheila L; Fent, Kenneth W; Gaines, Linda G T; Thomasen, Jennifer M; Whittaker, Stephen G; Ball, Louise M; Nylander-French, Leena A

Published In Biomarkers, (2011 May)

Abstract: We investigated the utility of 1,6-hexamethylene diamine (HDA) hemoglobin adducts as biomarkers of exposure to 1,6-hexamethylene diisocyanate (HDI) monomer. Blood samples from 15 spray painters applying HDI-containing paint were analyzed for hemoglobin HDA (HDA-Hb) and N-acetyl-1,6-hexamethylene diamine (monoacetyl-HDA-Hb) by GC-MS. HDA-Hb was detected in the majority of workers (ýýý1.2-37ýýýng/g Hb), whereas monoacetyl-HDA-Hb was detected in one worker (0.06ýýýng/g Hb). The stronger, positive association between HDA-Hb and cumulative HDI exposure (r(2)ýýý=ýýý0.3, pýýý<ýýý0.06) than same day exposure (pýýýýýýýýý0.13) indicates long-term elimination kinetics for HDA-Hb adducts. This association demonstrates the suitability of HDA-Hb adducts for further validation as a biomarker of HDI exposure.

PubMed ID: 21506697 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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