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Publication Detail

Title: Transcription initiation from within P elements generates hypomorphic mutations in Drosophila melanogaster.

Authors: LaFave, Matthew C; Sekelsky, Jeff

Published In Genetics, (2011 Jul)

Abstract: Numerous transposable element insertions in Drosophila melanogaster cause hypomorphic mutations. We report that transcription initiation within a region found in many P-element constructs provides an explanation for why some gene function is retained. We detected evidence of this transcription in four different types of P constructs, regardless of whether the insertion was in a coding exon, intron, 5' untranslated region, or upstream of the gene span.

PubMed ID: 21527778 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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