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Publication Detail

Title: Estrogens and prostate cancer: etiology, mediators, prevention, and management.

Authors: Ho, Shuk-Mei; Lee, Ming-Tsung; Lam, Hung-Ming; Leung, Yuet-Kin

Published In Endocrinol Metab Clin North Am, (2011 Sep)

Abstract: The mainstay targets for hormonal prostate cancer (PCa) therapies are based on negating androgen action. Recent epidemiologic and experimental data have pinpointed the key roles of estrogens in PCa development and progression. Racial and geographic differences, as well as age-associated changes, in estrogen synthesis and metabolism contribute significantly to the etiology. This article summarizes how different estrogens/antiestrogens/estrogen mimics contribute to prostate carcinogenesis, the roles of the different mediators of estrogen in the process, and the potentials of new estrogenic/antiestrogenic compounds for prevention and treatment of PCa.

PubMed ID: 21889723 Exiting the NIEHS site

MeSH Terms: Adenocarcinoma/epidemiology; Adenocarcinoma/etiology*; Adenocarcinoma/prevention & control; Adenocarcinoma/therapy*; Animals; Disease Susceptibility; Estrogens/metabolism; Estrogens/physiology*; Humans; Male; Models, Biological; Prostatic Neoplasms/epidemiology; Prostatic Neoplasms/etiology*; Prostatic Neoplasms/prevention & control; Prostatic Neoplasms/therapy*; Risk Factors

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