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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Transplacental carcinogenesis with dibenzo[def,p]chrysene (DBC): timing of maternal exposures determines target tissue response in offspring.

Authors: Shorey, Lyndsey E; Castro, David J; Baird, William M; Siddens, Lisbeth K; Löhr, Christiane V; Matzke, Melissa M; Waters, Katrina M; Corley, Richard A; Williams, David E

Published In Cancer Lett, (2012 Apr 01)

Abstract: Dibenzo[def,p]chrysene (DBC) is a transplacental carcinogen in mice (15mg/kg; gestation day (GD) 17). To mimic residual exposure throughout pregnancy, dams received four smaller doses of DBC (3.75mg/kg) on GD 5, 9, 13 and 17. This regimen alleviated the previously established carcinogenic responses in the thymus, lung, and liver. However, there was a marked increase in ovarian tumors (females) and hyperplastic testes (males). [(14)C]-DBC (GD 17) dosing revealed transplacental distribution to fetal tissues at 10-fold lower concentrations than in paired maternal tissue and residual [(14)C] 3weeks post-dose. This study highlights the importance of developmental stage in susceptibility to environmental carcinogens.

PubMed ID: 22085489 Exiting the NIEHS site

MeSH Terms: Animals; Aryl Hydrocarbon Hydroxylases/genetics; Aryl Hydrocarbon Hydroxylases/metabolism; Benzopyrenes/administration & dosage; Benzopyrenes/pharmacokinetics; Benzopyrenes/toxicity*; Carcinogens/administration & dosage; Carcinogens/pharmacokinetics; Carcinogens/toxicity*; Cytochrome P-450 CYP1B1; Female; Fetus/drug effects; Fetus/metabolism; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Gestational Age; Male; Maternal Exposure*; Maternal-Fetal Exchange*; Mice; Mice, 129 Strain; Neoplasms, Experimental/chemically induced*; Neoplasms, Experimental/pathology; Placental Circulation*; Pregnancy; Prenatal Exposure Delayed Effects*; Time Factors; Tissue Distribution

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