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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Control of skin cancer by the circadian rhythm.

Authors: Gaddameedhi, Shobhan; Selby, Christopher P; Kaufmann, William K; Smart, Robert C; Sancar, Aziz

Published In Proc Natl Acad Sci U S A, (2011 Nov 15)

Abstract: Skin cancer is the most common form of cancer in the United States. The main cause of this cancer is DNA damage induced by the UV component of sunlight. In humans and mice, UV damage is removed by the nucleotide excision repair system. Here, we report that a rate-limiting subunit of excision repair, the xeroderma pigmentosum group A (XPA) protein, and the excision repair rate exhibit daily rhythmicity in mouse skin, with a minimum in the morning and a maximum in the afternoon/evening. In parallel with the rhythmicity of repair rate, we find that mice exposed to UV radiation (UVR) at 4:00 AM display a decreased latency and about a fivefold increased multiplicity of skin cancer (invasive squamous cell carcinoma) than mice exposed to UVR at 4:00 PM. We conclude that time of day of exposure to UVR is a contributing factor to its carcinogenicity in mice, and possibly in humans.

PubMed ID: 22025708 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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