Title: Industrial toxicants and Parkinson's disease.

Authors: Caudle, W Michael; Guillot, Thomas S; Lazo, Carlos R; Miller, Gary W

Published In Neurotoxicology, (2012 Mar)

Abstract: The exposure of the human population to environmental contaminants is recognized as a significant contributing factor for the development of Parkinson's disease (PD) and other forms of parkinsonism. While pesticides have repeatedly been identified as risk factors for PD, these compounds represent only a subset of environmental toxicants that we are exposed to on a regular basis. Thus, non-pesticide contaminants, such as metals, solvents, and other organohalogen compounds have also been implicated in the clinical and pathological manifestations of these movement disorders and it is these non-pesticide compounds that are the subject of this review. As toxic exposures to these classes of compounds can result in a spectrum of PD or PD-related disorders, it is imperative to appreciate shared clinico-pathological characteristics or mechanisms of action of these compounds in order to further delineate the resultant disorders as well as identify improved preventive strategies or therapeutic interventions.

PubMed ID: 22309908

MeSH Terms: Environmental Exposure*; Hazardous Substances/toxicity*; Humans; Parkinson Disease/epidemiology*; Parkinson Disease/etiology*; Risk Factors