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National Institute of Environmental Health Sciences

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Publication Detail

Title: A sterol-binding protein integrates endosomal lipid metabolism with TOR signaling and nitrogen sensing.

Authors: Mousley, Carl J; Yuan, Peihua; Gaur, Naseem A; Trettin, Kyle D; Nile, Aaron H; Deminoff, Stephen J; Dewar, Brian J; Wolpert, Max; Macdonald, Jeffrey M; Herman, Paul K; Hinnebusch, Alan G; Bankaitis, Vytas A

Published In Cell, (2012 Feb 17)

Abstract: Kes1, and other oxysterol-binding protein superfamily members, are involved in membrane and lipid trafficking through trans-Golgi network (TGN) and endosomal systems. We demonstrate that Kes1 represents a sterol-regulated antagonist of TGN/endosomal phosphatidylinositol-4-phosphate signaling. This regulation modulates TOR activation by amino acids and dampens gene expression driven by Gcn4, the primary transcriptional activator of the general amino acid control regulon. Kes1-mediated repression of Gcn4 transcription factor activity is characterized by nonproductive Gcn4 binding to its target sequences, involves TGN/endosome-derived sphingolipid signaling, and requires activity of the cyclin-dependent kinase 8 (CDK8) module of the enigmatic "large Mediator" complex. These data describe a pathway by which Kes1 integrates lipid metabolism with TORC1 signaling and nitrogen sensing.

PubMed ID: 22341443 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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