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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Nasal cell DNA methylation, inflammation, lung function and wheezing in children with asthma.

Authors: Baccarelli, Andrea; Rusconi, Franca; Bollati, Valentina; Catelan, Dolores; Accetta, Gabriele; Hou, Lifang; Barbone, Fabio; Bertazzi, Pier Alberto; Biggeri, Annibale

Published In Epigenomics, (2012 Feb)

Abstract: DNA methylation is increasingly proposed as a mechanism for underlying asthma-related inflammation. However, epigenetic studies are constrained by uncertainties on whether samples that can be easily collected in human individuals can provide informative results.Two nasal cell DNA samples were collected on different days by nasal brushings from 35 asthmatic children aged between 8 and 11 years old. We correlated DNA methylation of IL-6, iNOS, Alu and LINE-1 with fractional exhaled nitric oxide, forced expiratory volume in 1 s and wheezing.Fractional exhaled nitric oxide increased in association with lower promoter methylation of both IL-6 (+29.0%; p = 0.004) and iNOS (+41.0%; p = 0.002). Lower IL-6 methylation was nonsignificantly associated with wheezing during the week of the study (odds ratio = 2.3; p = 0.063).Our findings support the use of nasal cell DNA for human epigenetic studies of asthma.

PubMed ID: 22332661 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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