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National Institute of Environmental Health Sciences

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Publication Detail

Title: The TBX21 transcription factor T-1993C polymorphism is associated with decreased IFN-γ and IL-4 production by primary human lymphocytes.

Authors: Fyall, K M; Fong, A M; Rao, S B; Ibrahim, J G; Waxweiler, W T; Thomas, N E

Published In Hum Immunol, (2012 Jun)

Abstract: T-bet is a transcription factor that drives the Th1 immune response primarily through promoting expression of the IFN-γ gene. Polymorphisms in the T-bet gene, TBX21, have been associated with immune-mediated diseases such as asthma and systemic sclerosis. We found that the TBX21 promoter polymorphism T-1993C is associated with a significant decrease in IL-4 and IFN-γ production by stimulated primary human lymphocytes from healthy participants.

PubMed ID: 22521571 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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