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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Strategies to decrease ongoing oxidant burden in chronic obstructive pulmonary disease.

Authors: Rahman, Irfan; Kinnula, Vuokko L

Published In Expert Rev Clin Pharmacol, (2012 May)

Abstract: Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality and morbidity globally, and its development is mainly associated with tobacco/biomass smoke-induced oxidative stress. Hence, targeting systemic and local oxidative stress with agents that can balance the antioxidant/redox system can be expected to be useful in the treatment of COPD. Preclinical and clinical trials have revealed that antioxidants/redox modulators can detoxify free radicals and oxidants, control expression of redox and glutathione biosynthesis genes, chromatin remodeling and inflammatory gene expression; and are especially useful in preventing COPD exacerbations. In this review, various novel approaches and problems associated with these approaches in COPD are reviewed.

PubMed ID: 22697592 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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