Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Demonstration of starter unit interprotein transfer from a fatty acid synthase to a multidomain, nonreducing polyketide synthase.

Authors: Foulke-Abel, Jennifer; Townsend, Craig A

Published In Chembiochem, (2012 Sep 03)

Abstract: The pathway for substrate transacylation between a fungal type I fatty acid synthase (FAS) and a nonreducing polyketide synthase (NR-PKS) was determined by in vitro reconstitution of dissected domains. System kinetics were influenced by domain dissections, and the FAS phosphopantetheinyl transferase (PPT) monodomain exhibited coenzyme A selectivity for the post-translational activation of the FAS acyl carrier protein (ACP).

PubMed ID: 22807303 Exiting the NIEHS site

MeSH Terms: Acyl Carrier Protein/metabolism; Acylation; Bacterial Proteins/chemistry; Bacterial Proteins/metabolism; Coenzyme A/metabolism; Fatty Acid Synthases/chemistry; Fatty Acid Synthases/metabolism*; Fatty Acids/metabolism; Polyketide Synthases/chemistry; Polyketide Synthases/metabolism*; Protein Interaction Maps*; Protein Structure, Tertiary; Saccharomyces cerevisiae/chemistry; Saccharomyces cerevisiae/enzymology*; Saccharomyces cerevisiae/metabolism; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Transferases (Other Substituted Phosphate Groups)/chemistry; Transferases (Other Substituted Phosphate Groups)/metabolism

Back
to Top