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Publication Detail

Title: Demonstration of starter unit interprotein transfer from a fatty acid synthase to a multidomain, nonreducing polyketide synthase.

Authors: Foulke-Abel, Jennifer; Townsend, Craig A

Published In Chembiochem, (2012 Sep 03)

Abstract: The pathway for substrate transacylation between a fungal type I fatty acid synthase (FAS) and a nonreducing polyketide synthase (NR-PKS) was determined by in vitro reconstitution of dissected domains. System kinetics were influenced by domain dissections, and the FAS phosphopantetheinyl transferase (PPT) monodomain exhibited coenzyme A selectivity for the post-translational activation of the FAS acyl carrier protein (ACP).

PubMed ID: 22807303 Exiting the NIEHS site

MeSH Terms: Acyl Carrier Protein/metabolism; Acylation; Bacterial Proteins/chemistry; Bacterial Proteins/metabolism; Coenzyme A/metabolism; Fatty Acid Synthases/chemistry; Fatty Acid Synthases/metabolism*; Fatty Acids/metabolism; Polyketide Synthases/chemistry; Polyketide Synthases/metabolism*; Protein Interaction Maps*; Protein Structure, Tertiary; Saccharomyces cerevisiae/chemistry; Saccharomyces cerevisiae/enzymology*; Saccharomyces cerevisiae/metabolism; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Transferases (Other Substituted Phosphate Groups)/chemistry; Transferases (Other Substituted Phosphate Groups)/metabolism

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