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National Institute of Environmental Health Sciences

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Publication Detail

Title: Environmental control of the calicheamicin polyketide synthase leads to detection of a programmed octaketide and a proposal for enediyne biosynthesis.

Authors: Belecki, Katherine; Townsend, Craig A

Published In Angew Chem Int Ed Engl, (2012 Nov 5)

Abstract: A light in the dark: the fermentation products of the polyketide synthase CalE8 (without its cognate thioesterase) were identified and gave some insight into the elusive early steps of calicheamicin biosynthesis. Fermentation in either the light or dark resulted in different proportions of a new octaketide and led to an updated mechanistic proposal.

PubMed ID: 23042574 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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