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Publication Detail

Title: Analysis of the cercosporin polyketide synthase CTB1 reveals a new fungal thioesterase function.

Authors: Newman, Adam G; Vagstad, Anna L; Belecki, Katherine; Scheerer, Jonathan R; Townsend, Craig A

Published In Chem Commun (Camb), (2012 Dec 14)

Abstract: The polyketide synthase CTB1 is demonstrated to catalyze pyrone formation thereby expanding the known biosynthetic repertoire of thioesterase domains in iterative, non-reducing polyketide synthases.

PubMed ID: 23108075 Exiting the NIEHS site

MeSH Terms: Ascomycota/chemistry; Ascomycota/enzymology*; Ascomycota/metabolism; Perylene/analogs & derivatives*; Perylene/chemistry; Perylene/metabolism; Polyketide Synthases/chemistry; Polyketide Synthases/metabolism*; Protein Structure, Tertiary; Pyrones/chemistry; Pyrones/metabolism*; Thiolester Hydrolases/chemistry; Thiolester Hydrolases/metabolism

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