Title: Analysis of the cercosporin polyketide synthase CTB1 reveals a new fungal thioesterase function.
Authors: Newman, Adam G; Vagstad, Anna L; Belecki, Katherine; Scheerer, Jonathan R; Townsend, Craig A
Published In Chem Commun (Camb), (2012 Dec 14)
Abstract: The polyketide synthase CTB1 is demonstrated to catalyze pyrone formation thereby expanding the known biosynthetic repertoire of thioesterase domains in iterative, non-reducing polyketide synthases.
PubMed ID:
23108075
MeSH Terms: Ascomycota/chemistry; Ascomycota/enzymology*; Ascomycota/metabolism; Perylene/analogs & derivatives*; Perylene/chemistry; Perylene/metabolism; Polyketide Synthases/chemistry; Polyketide Synthases/metabolism*; Protein Structure, Tertiary; Pyrones/chemistry; Pyrones/metabolism*; Thiolester Hydrolases/chemistry; Thiolester Hydrolases/metabolism