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National Institute of Environmental Health Sciences

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Publication Detail

Title: Regulation of synaptojanin 2 5'-phosphatase activity by Src.

Authors: Chuang, Yayu; Xu, Xiaonan; Kwiatkowska, Aneta; Tsapraillis, George; Hwang, Hyonson; Petritis, Konstantinos; Flynn, Dan; Symons, Marc

Published In Cell Adh Migr, (2012 Nov-Dec)

Abstract: Synaptojanin 2 (SYNJ2) is a phosphatidylinositol (PI) phosphatase that controls two distinct functions, clathrin-mediated endocytosis and tumor cell invadopodia formation and invasion. Here, we identify a number of novel SYNJ2 binding partners, several of which have previously been shown to be necessary for invadopodia formation or clathrin-mediated endocytosis. We focus on Src family kinases. We found that Src phosphorylates SYNJ2 on Tyr ( 490) , thereby stimulating SYNJ2 5'-phosphatase activity in vitro. We also provide evidence that Src-mediated phosphorylation of SYNJ2 contributes to invadopodia formation.

PubMed ID: 23076136 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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