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National Institute of Environmental Health Sciences

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Publication Detail

Title: In vitro modeling of human bocavirus 1 infection of polarized primary human airway epithelia.

Authors: Deng, Xuefeng; Yan, Ziying; Luo, Yong; Xu, Jian; Cheng, Fang; Li, Yi; Engelhardt, John F; Qiu, Jianming

Published In J Virol, (2013 Apr)

Abstract: Human bocavirus 1 (HBoV1) is an emerging human-pathogenic respiratory virus. We characterized two important features of HBoV1 infection in polarized primary human airway epithelia (HAE). Apical HBoV1 infection of HAE at a low multiplicity of infection causes disruption of the tight junction barrier, loss of cilia, and epithelial cell hypertrophy, which are hallmarks of the airway epithelial damage caused by HBoV1 infection. HBoV1 also infects HAE from the basolateral surface productively, although less efficiently, and this also leads to the characteristic airway epithelial damage.

PubMed ID: 23345515 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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