Title: Scout-view assisted interior micro-CT.

Authors: Sen Sharma, Kriti; Holzner, Christian; Vasilescu, Dragoş M; Jin, Xin; Narayanan, Shree; Agah, Masoud; Hoffman, Eric A; Yu, Hengyong; Wang, Ge

Published In Phys Med Biol, (2013 Jun 21)

Abstract: Micro computed tomography (micro-CT) is a widely-used imaging technique. A challenge of micro-CT is to quantitatively reconstruct a sample larger than the field-of-view (FOV) of the detector. This scenario is characterized by truncated projections and associated image artifacts. However, for such truncated scans, a low resolution scout scan with an increased FOV is frequently acquired so as to position the sample properly. This study shows that the otherwise discarded scout scans can provide sufficient additional information to uniquely and stably reconstruct the interior region of interest. Two interior reconstruction methods are designed to utilize the multi-resolution data without significant computational overhead. While most previous studies used numerically truncated global projections as interior data, this study uses truly hybrid scans where global and interior scans were carried out at different resolutions. Additionally, owing to the lack of standard interior micro-CT phantoms, we designed and fabricated novel interior micro-CT phantoms for this study to provide means of validation for our algorithms. Finally, two characteristic samples from separate studies were scanned to show the effect of our reconstructions. The presented methods show significant improvements over existing reconstruction algorithms.

PubMed ID: 23732478

MeSH Terms: No MeSH terms associated with this publication