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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Sulfate conjugates are urinary markers of inhalation exposure to 4-chlorobiphenyl (PCB3).

Authors: Dhakal, Kiran; Adamcakova-Dodd, Andrea; Lehmler, Hans-Joachim; Thorne, Peter S; Robertson, Larry W

Published In Chem Res Toxicol, (2013 Jun 17)

Abstract: PCBs are contaminants in the air of older buildings and cities, which raises the concern of inhalation exposure. No reliable biomarker of such exposure is available. We exposed rats to air containing 2 mg/m(3) PCB3 via nose-only inhalation for 2 h, collected urine, and analyzed it by LC/MS. Each rat inhaled an estimated dose of 35 μg PCB3, and excreted 27 ± 2% of it as sulfates within 24 h. Peak excretion occurred within 6 h. PCB sulfates were stable in urine for at least three days at room temperature without chemical preservatives. These data support the use of PCB sulfate conjugates as suitable urinary biomarkers of PCB3 and other airborne PCBs.

PubMed ID: 23713983 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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