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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Differential effects of inorganic lead on hippocampal long-term potentiation in young rats in vivo.

Authors: Zaiser, A E; Miletic, V

Published In Brain Res, (2000 Sep 08)

Abstract: Tetanic stimulation at 50 Hz elicited long-term potentiation (LTP) in the hippocampal CA1 region of 28-day-old control animals. In contrast, no significant potentiation was seen following the same tetanus in animals chronically exposed to 1000 ppm of lead acetate during development. Gender differences were observed in animals exposed to 500 ppm of lead. In females, LTP was significantly attenuated, while in males the LTP was identical to that of controls.

PubMed ID: 10973610 Exiting the NIEHS site

MeSH Terms: Action Potentials/drug effects; Animals; Animals, Newborn; Electric Stimulation; Female; Hippocampus/physiology*; Long-Term Potentiation/drug effects*; Male; Organometallic Compounds/pharmacology*; Rats; Rats, Sprague-Dawley; Reference Values; Sex Characteristics

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