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Publication Detail

Title: Damage control: management of cellular stress by the NLRP3 inflammasome.

Authors: Haasken, Stefanie; Sutterwala, Fayyaz S

Published In Eur J Immunol, (2013 Aug)

Abstract: The NLRP3 inflammasome plays a critical role in regulating inflammatory and cell death pathways in response to a diverse array of stimuli. Activation of the NLRP3 inflammasome results in activation of the cysteine protease caspase-1 and the subsequent processing and secretion of the proinflammatory cytokines IL-1β and IL-18. In this issue of the European Journal of Immunology, Licandro et al. [Eur. J. Immunol. 2013. 43, 2126-2137] show that the NLRP3 inflammasome contributes to oxidative DNA damage. In addition, activation of the NLRP3 inflammasome modulates a number of pathways involved in DNA damage repair, cell cycle, and apoptosis, suggesting a novel role for the NLRP3 inflammasome in DNA damage responses following cellular stress.

PubMed ID: 23928964 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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