Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

National Institute of Environmental Health Sciences

Use this QR code to view the newest version of this document
Use this QR code to view the newest version of this document

Your Environment. Your Health.

Publication Detail

Title: Evaluation of neurobehavioral and neuroinflammatory end-points in the post-exposure period in rats sub-acutely exposed to manganese.

Authors: Santos, Dinamene; Dinamene, Santos; Batoréu, M Camila; Camila, Batoreu M; Tavares de Almeida, I; Davis Randall, L; Mateus, M Luísa; Luisa, Mateus M; Andrade, Vanda; Vanda, Andrade; Ramos, Ruben; Ruben, Ramos; Torres, Edite; Edite, Torres; Aschner, Michael; Michael, Aschner; Marreilha dos Santos, A P; Marreilha Dos Santos, A P

Published In Toxicology, (2013 Dec 06)

Abstract: Manganese (Mn) can cause manganism, a neurological disorder similar to Parkinson' Disease (PD). The neurobehavioral and neuroinflammatory end-points in the Mn post exposure period have not been studied yet. Rats were injected on alternate days with 8 doses of MnCl2 (25mg/kg) or saline, then euthanized 1, 10, 30 or 70 days following the last dose. Whole-blood (WB) (p<0.05), urine (p<0.05) and brain cortical (p<0.0001) Mn levels were significantly increased 24h after the last dose. Decreases in the rats' ambulation were noted 1, 10 and 30 days after the last Mn dose (p<0.001; p<0.05; p<0.001, respectively) and also in the rearing activity at the four time-points (p<0.05). Cortical glial fibrillary acid protein immunoreactivity (GFAP-ir) was significantly increased at 1, 10, 30 (p<0.0001) and 70 (p<0.001) days after the last Mn dose, as well as tumor necrosis α (TNF-α) levels (p<0.05) but just on day 1. Taken together, the results show that, during the 70-day clearance phase of Mn, the recovery is not immediate as behavioral alterations and neuroinflammation persist long after Mn is cleared from the cortical brain compartment.

PubMed ID: 24060432 Exiting the NIEHS site

MeSH Terms: Animals; Behavior, Animal/drug effects*; Brain/metabolism; Cerebral Cortex/chemistry; Cerebral Cortex/metabolism; Chlorides; Dose-Response Relationship, Drug; Endpoint Determination; Glial Fibrillary Acidic Protein/metabolism; Immunohistochemistry; Inflammation/chemically induced; Inflammation/pathology*; Male; Manganese Compounds; Manganese Poisoning/pathology*; Manganese Poisoning/psychology*; Manganese/blood; Manganese/metabolism; Manganese/urine; Motor Activity/drug effects; Rats; Rats, Wistar; Spectrophotometry, Atomic

Back
to Top