Title: Association between herpes simplex virus type 1 and Helicobacter pylori in US adolescents.

Authors: Baccaglini, Lorena; Schoenbach, Victor J; Poole, Charles; McKaig, Rosemary G; Ibrahim, Joseph; Baric, Ralph S; Wiesen, Chris

Published In Oral Surg Oral Med Oral Pathol Oral Radiol Endod, (2006 Jan)

Abstract: OBJECTIVE: To understand how Helicobacter pylori infection is acquired and the role that herpes simplex virus type 1 (HSV-1) may have, we determined whether an association between HSV and H pylori exists at the individual level and for what reason. STUDY DESIGN: Data were collected from 1,090 participants aged 12-19 years during phase 1 (1988-1991) of the NHANES III. Generalized estimating equations were used to estimate prevalence ratios (PR). RESULTS: The crude overall PR and 95% CI for H pylori seropositivity comparing HSV+ to HSV- individuals was 2.20 (1.69-2.85). In large urban households the PR adjusted for poverty level and race/ethnicity was twice that in small nonurban households (2.27 versus 1.15, respectively). CONCLUSIONS: Overall, HSV-1 seropositivity is associated with a higher H pylori seroprevalence. The negligible association found in some strata suggests that shared environmental factors or routes of transmission rather than biologic reasons may be primarily responsible for this association.

PubMed ID: 16360609

MeSH Terms: No MeSH terms associated with this publication