Title: Tumor resident mesenchymal stromal cells endow naïve stromal cells with tumor-promoting properties.

Authors: Ren, G; Liu, Y; Zhao, X; Zhang, J; Zheng, B; Yuan, Z-R; Zhang, L; Qu, X; Tischfield, J A; Shao, C; Shi, Y

Published In Oncogene, (2014 Jul 24)

Abstract: Bone marrow mesenchymal stem/stromal cells (BM-MSCs) can infiltrate into tumors and subsequently evolve into tumor resident MSCs in tumor microenvironment. In this study, using a mouse lymphoma model, we showed that the lymphoma resident MSCs (L-MSCs) are able to confer tumor-promoting property to the naïve cocultured BM-MSCs. Examination of cytokines and chemokines showed that post exposure to L-MSCs, BM-MSCs acquired an expression profile that is similar to that in L-MSCs. In vivo, BM-MSCs educated by L-MSCs (BM-L-MSCs) possess a greatly enhanced ability in promoting lymphoma growth. Consistent with an elevated CCL-2 expression in BM-L-MSCs, the tumor-promoting effect of BM-L-MSCs largely depends on CCR2-mediated macrophage recruitment to tumor sites. We further showed that the transmission of tumor-promoting effect is partially mediated by soluble factors. Our findings thus revealed a novel reinforcing mechanism in the maintenance of tumor microenvironment.

PubMed ID: 24077286

MeSH Terms: No MeSH terms associated with this publication