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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Biodegradable particles as vaccine antigen delivery systems for stimulating cellular immune responses.

Authors: Joshi, Vijaya B; Geary, Sean M; Salem, Aliasger K

Published In Hum Vaccin Immunother, (2013 Dec)

Abstract: There is a need for both new and improved vaccination formulations for a range of diseases for which current vaccines are either inadequate or non-existent. Biodegradable polymer-based vaccines fulfill many of the desired properties in achieving effective long-term protection in a manner that is safe, economical, and potentially more practicable on a global scale. Here we discuss some of the work performed with micro/nanoparticles made from either synthetic (poly[lactic-co-glycolic acid] [PLGA] and polyanhydrides) or natural (chitosan) biodegradable polymers. Our attention is focused on, but not limited to, the generation of antitumor immunity where we stress the importance of particle size and co-delivery of antigen and adjuvant.

PubMed ID: 23978910 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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