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Publication Detail

Title: Design of the Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS).

Authors: Couper, David; LaVange, Lisa M; Han, MeiLan; Barr, R Graham; Bleecker, Eugene; Hoffman, Eric A; Kanner, Richard; Kleerup, Eric; Martinez, Fernando J; Woodruff, Prescott G; Rennard, Stephen; SPIROMICS Research Group

Published In Thorax, (2014 May)

Abstract: Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS) is a multicentre observational study of chronic obstructive pulmonary disease (COPD) designed to guide future development of therapies for COPD by providing robust criteria for subclassifying COPD participants into groups most likely to benefit from a given therapy during a clinical trial, and identifying biomarkers/phenotypes that can be used as intermediate outcomes to reliably predict clinical benefit during therapeutic trials. The goal is to enrol 3200 participants in four strata. Participants undergo a baseline visit and three annual follow-up examinations, with quarterly telephone calls. Adjudication of exacerbations and mortality will be undertaken.

PubMed ID: 24029743 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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