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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Effects of air pollutants on innate immunity: the role of Toll-like receptors and nucleotide-binding oligomerization domain-like receptors.

Authors: Bauer, Rebecca N; Diaz-Sanchez, David; Jaspers, Ilona

Published In J Allergy Clin Immunol, (2012 Jan)

Abstract: Interactions between exposure to ambient air pollutants and respiratory pathogens have been shown to modify respiratory immune responses. Emerging data suggest key roles for Toll-like receptor (TLR) and nucleotide-binding oligomerization domain-like receptor (NLR) signaling in pathogen-induced immune responses. Similarly, immune responses elicited by exposure to air pollutants are mediated by specific TLR- and NLR-dependent mechanisms. This review article will summarize current knowledge about how air pollutants modify TLR- and NLR-dependent signaling and host defense responses in the lung.

PubMed ID: 22196521 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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