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Title: Interaction of lipid vesicle with silver nanoparticle-serum albumin protein corona.

Authors: Chen, Ran; Choudhary, Poonam; Schurr, Ryan N; Bhattacharya, Priyanka; Brown, Jared M; Chun Ke, Pu

Published In Appl Phys Lett, (2012 Jan 02)

Abstract: The physical interaction between a lipid vesicle and a silver nanoparticle (AgNP)-human serum albumin (HSA) protein "corona" has been examined. Specifically, the binding of AgNPs and HSA was analyzed by spectrophotometry, and the induced conformational changes of the HSA were inferred from circular dichroism spectroscopy. The fluidity of the vesicle, a model system for mimicking cell membrane, was found to increase with the increased exposure to AgNP-HSA corona, though less pronounced compared to that induced by AgNPs alone. This study offers additional information for understanding the role of physical forces in nanoparticle-cell interaction and has implications for nanomedicine and nanotoxicology.

PubMed ID: 22271932 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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