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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Bone marrow-derived myofibroblasts promote colon tumorigenesis through the IL-6/JAK2/STAT3 pathway.

Authors: Zhu, Liming; Cheng, Xiaojiao; Ding, Yanfei; Shi, Jindong; Jin, Huanyu; Wang, Hong; Wu, Yunlin; Ye, Jing; Lu, Yiming; Wang, Timothy C; Yang, Chung S; Tu, Shui Ping

Published In Cancer Lett, (2014 Feb 1)

Abstract: Bone marrow-derived myofibroblasts (BMFs) have been shown to promote tumor growth. Here, we found that BMFs or BMF conditioned medium (BMF-CM) induced cancer stem cell-like sphere formation of colon cancer cells. The co-cultured BMFs, but not co-cultured cancer cells, expressed higher levels of IL-6 than BMFs or cancer cells cultured alone. Anti-mouse IL-6 neutralizing antibody, JAK2 inhibitors and STAT3 knockdown in mouse cancer cells reduced BMF- and BMF-CM-induced sphere formation of colon cancer cells. When co-injected, BMFs significantly enhanced tumorigenesis of colon cancer cells in mice. Our results demonstrate that BMFs promote tumorigenesis via the activation of the IL-6/JAK2/STAT3 pathway.

PubMed ID: 24145153 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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